Table 4.
Small-molecule drugs and chemical compounds that regulate gene expression in an opposite manner to BNT162b2.
| Compound | Score | Description | Links to hypothalamic-pituitary-ovarian function |
|---|---|---|---|
| Droxinostat | −94.51 | HDAC inhibitor | 149 |
| Metyrapone | −93.62 | Cytochrome P450 inhibitor | 150,151 |
| Perospirone | −92.07 | Dopamine receptor antagonist | 152 |
| Nabumetone | −88.8 | Cyclooxygenase inhibitor | 153 |
| Salbutamol | −87.35 | Adrenergic receptor agonist | 154,155 |
| VU-0415374-1 | −86.32 | Glutamate receptor modulator | 156 |
| Bromfenac | −83.64 | Cyclooxygenase inhibitor | 153,157 |
| PF-3845 | −82.22 | FAAH inhibitor | 158 |
| Hexylresorcinol | −80.48 | Local anesthetic | 159 |
| PPT | −80.07 | Estrogen receptor agonist | 160 |