Fig. 3.
Capability of TFPAI to detect IVH and PVH. (a) Reconstructed US image (coronal plane) showing lateral ventricle location. A corresponding photograph of the same anatomical cross-section is shown in the inset, (b) lateral ventricles (yellow dashed box in (a)) magnified before needle insertion, (c) lateral ventricles (yellow dashed box in (a)) magnified after needle insertion, (d) reconstructed PA image overlaid on the US image demonstrating IVH within a ventricle, (e) reconstructed PA image overlaid on the US demonstrating PVH just outside the ventricular space, (f-i) averaged pixel values of the injected ROIi in sheep #1 and #2 shown separately for different injection volumes (mean and range): (f) in the US image to model PVH, (g) in the PA image to model PVH, (h) in the US image to model IVH, (i) in the PA image to model IVH. ROI: region of interest; PA: photoacoustic; US: ultrasound; IVH: intraventricular hemorrhage; PVH: periventricular hemorrhage. As described in the text, the plane of the brain shown in b/c is several mm away from the plane shown in figures d/e in order to illustrate needle placement.