Table 1.
Distribution of cases with spontaneous menopause at age < 40 and 40–45 years, and controls with age at menopause > 45 years according to selected factors
| No. of cases | controls | OR(95% CI) | adjusted OR (95% CI)** | ||||
|---|---|---|---|---|---|---|---|
| Age at menopause < 40years | Age at menopause 40–45 years | Age at menopause >45years |
Age at menopause < 40years | Age at menopause 40–45 years | Age at menopause < 40years | Age at menopause 40–45 years | |
| Education | |||||||
| illiterate | 18(51.4) | 153(58.4) | 574(58.6) | 1.33(0.65,2.69) | 1.34(0.68,2.63) | 1.52(0.71,3.26) | 1.03(0.75,1.42) |
| literate | 17(48.6) | 109(41.6) | 405(41.4) | 1+ | 1+ | 1+ | 1+ |
| Age at menarche (years) | |||||||
| ≤ 11 | 2(5.7) | 23(8.8) | 79(8.1) | 0.55(0.13,2.37) | 1.15(0.69,1.90) | 0.43(0.09,1.87) | 1.14(0.69,1.89) |
| 12 | 2(5.7) | 44(216.8) | 139(14.2) | 0.31(0.07,1.34) | 1.25(0.85,1.85) | 0.26(0.06,1.11) | 1.24(0.84,1.84) |
| 13 | 7(20.0) | 63(24.0) | 237(24.3) | 0.64(0.27,1.51) | 1.05(0.75,1.47) | 0.55(0.23,1.32) | 1.05(0.74,1.47) |
| ≥ 14 | 24(68.6) | 132(50.4) | 522(53.4) | 1+ | 1+ | 1+ | 1+ |
| Use Infertility Drug | |||||||
| Yes | 4(11.4) | 15(5.7) | 51(5.2) | 2.35(0.79,6.90) | 1.10(0.61,1.99) | 1.93(0.64,5.81) | 1.09(0.60,1.98) |
| No | 31(88.6) | 247(94.3) | 928(94.8) | 1+ | 1+ | 1+ | 1+ |
| Alive Childbirth No. | |||||||
| 0 | 4(11.4) | 6(2.3) | 13(1.3) | 15.24(4.50,51.57) | 1.82(0.68,4.83) | 12.21(3.49,42.64) | 0.99(0.97,1.02) |
| 1 | 2(5.7) | 5(1.9) | 13(1.3) | 7.62(1.59,36.41) | 1.51(0.53,4.29) | 5.42(1.08,27.23) | 1.81(0.68,4.83) |
| 2 | 3(8.6) | 9(3.4) | 28(2.9) | 5.31(1.47,19.16) | 1.26(0.59,2.72) | 3.87(1.03,14.46) | 1.51(0.53,4.30) |
| 3 | 9(25.7) | 28(10.7) | 82(8.4) | 5.44(3.35,12.58) | 1.34(0.85,2.12) | 3.90(1.59,9.56) | 1.34(0.84,2.15) |
| ≥ 4 | 17(48.6) | 214(81.7) | 842(86.1) | 1+ | 1+ | 1+ | 1+ |
| Mean(sd) | 4.29(3.06) | 5.86(2.78) | 6.01(2.53) |
Trend p-value < 0.001 |
Trend p-value = 0.07 |
Trend p-value < 0.001 |
Trend p-value = 0.08 |
| Oral contraceptive use | |||||||
| No | 23(65.7) | 156(59.5) | 522(53.3) | 1.68(0.83,3.41) | 1.29(0.98,1.69) | 1.94(0.95,3.98) | 1.30(0.99,1.72) |
| Yes | 12(34.3) | 106(40.5) | 457(46.7) | 1+ | 1+ | ||
| Has Job | |||||||
| No | 30(85.7) | 246(93.9) | 928(94.8) | 0.33(0.12,0.88) | 0.84(0.47,1.51) | 0.50((0.18,1.39) | 0.86(0.48,1.55) |
| Yes | 5(14.3) | 16(6.1) | 51(5.2) | 1+ | 1+ | 1+ | 1+ |
| Age at First Alive Childbirth | |||||||
| > 18 year | 7(22.6) | 74(28.9) | 322(33.4) | 0.58(0.25,1.36) | 0.81(0.59,1.09) | 0.59(0.25,1.39) | 0.81(0.59,1.09) |
| 18–35 year | 24(77.4) | 180(70.3) | 634(65.8) | 1+ | 1+ | 1+ | 1+ |
| > 35 year | 0 | 2(0.8) | 7(0.7) | * | * | ||
| Breastfeeding duration | |||||||
|
Mean(sd) Trend p-value = 0.002 |
69.16(39.7) | 96.71(49.6) | 101.55(52.3) | 0.98(0.97,0.99) | 0.99(0.98,1.01) | 0.98(0.98,0.99) | 1.01(0.99,1.02) |
Odds ratios were estimated using the unconditional multiple logistic regression (MLR).
*Merge into the second category to fit the regression model because of low sample size.
** Adjusted for age at interview.