Table 2.

Ranking of twelve best biomarkers according to Youden index

	Any stage		Transmural		Overall
	Biomarker	Youden index	Biomarker	Youden index	Biomarker	Youden index
1	IMA	0.85	I-FABP urine	0.77	IMA *	0.85
2	IL-6	0.82	IL-6	0.73	IL-6 #	0.79
3	PCT	0.68	D-dimer	0.71	I-FABP urine	0.67
4	I-FABP serum	0.63	I-FABP serum	0.68	PCT	0.67
5	alpha-GST	0.61	PCT	0.62	I-FABP serum	0.64
6	CRP	0.60	CRP	0.56	alpha-GST *	0.61
7	I-FABP urine	0.58	L-lactate	0.50	D-dimer	0.60
8	D-dimer	0.57	D-lactate	0.38	CRP	0.58
9	NLR	0.54	WBC	0.37	D-lactate	0.55
10	D-lactate	0.50	LDH	0.34	NLR	0.47
11	Citrulline	0.46	PLR	0.31	Citrulline *	0.46
12	L-lactate	0.42	pH	0.18	L-lactate	0.44

Alpha-GST—alpha glutathione S transferase (alpha-GST); CRP—C-reactive protein; I-FABP—intestinal fatty acid-binding protein; IL-6—interleukin 6; IMA—ischaemia-modified albumin; LDH—lactate dehydrogenase; NLR—neutrophil–lymphocyte ratio; PCT—procalcitonin; PLR—platelet–lymphocyte ratio; WBC—white blood cell count

Any stage—studies assessing different stages of AMI, including but not limited to non-transmural and transmural; Transmural—studies assessing transmural AMI, with control group including non-transmural AMI; Overall—all studies pooled independent of stage and type of AMI

*No study on transmural acute mesenteric ischaemia of any type

^#No study on non-occlusive mesenteric ischaemia