Table 4.
WGS performance in identifying drug-resistance mechanisms of MDR-Kp strains
| Type of antibiotics | Antibiotics | Sensitivity (%) | Specificity (%) | PPV (%) | NPV (%) | Accuracy (%) | |
|---|---|---|---|---|---|---|---|
| β-lactams | Penicillins | Ticarcillin | 100 | / | 100 | / | 100 |
| Piperacillin | 100 | / | 100 | / | 100 | ||
|
Amoxicillin/ Clavulanic acid |
100 | / | 100 | / | 100 | ||
| Cephalosporins | Cephalothin | 60 | / | 100 | 0 | 60 | |
| Cefuroxime | 60 | / | 100 | 0 | 60 | ||
| Cefotaxime | 100 | / | 100 | / | 100 | ||
| Ceftazidime | 100 | / | 100 | / | 100 | ||
| Cefepime | 100 | 50 | 94.1 | / | 94.4 | ||
| Cefazolin | 87.5 | / | 100 | 0 | 87.5 | ||
| Cefoxitin | 57.1 | 100 | 100 | 25 | 62.5 | ||
| Ceftriaxone | 100 | / | 100 | / | 100 | ||
| Carbapenems | Imipenem | 87.5 | 100 | 100 | 50 | 88.9 | |
| Meropenem | 100 | / | 100 | / | 100 | ||
| Ertapenem | \ | 100 | \ | 100 | 100 | ||
| Penicillin/β-lactamase inhibitor |
Piperacillin/ Tazobactam |
93.3 | 100 | 100 | 75 | 94.4 | |
| Monobactams | Aztreonam | 100 | 0 | 77.8 | 0 | 77.8 | |
| Quinolones | Moxifloxacin | 90 | / | 100 | / | 90 | |
| Norfloxacin | 90 | / | 100 | / | 90 | ||
| Ciprofloxacin | 83.3 | / | 100 | 0 | 83.3 | ||
| Levofloxacin | 77.8 | / | 100 | 0 | 77.8 | ||
| Aminoglycosides | Tobramycin | 100 | 66.7 | 93.8 | 100 | 94.4 | |
| Amikacin | 100 | 100 | 100 | 100 | 100 | ||
| Tetracyclines | Tetracycline | 71.4 | / | 100 | 60 | 80 | |
| Doxycycline | 71.4 | 100 | 100 | 60 | 80 | ||
Value not available due to no sensitive strains (/) or no resistant strains (\) determined by conventional drug sensitivity test. PPV, positive prediction value; NPV, negative prediction value