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. 2023 Sep 2;21:588. doi: 10.1186/s12967-023-04468-x

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© The Author(s) 2023

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated in a credit line to the data.

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Fig. 9 — Two different LGG clusters were delineated by consensus clustering. A, B Consensus clustering CDF for k = 2 to 9. C The consensus clustering with k = 2. D Kaplan–Meier survival curves of LGG patients’ OS among the two subgroups. E tSNE analysis and PCA analysis between two different subgroups. F Heatmap showing the between two different subgroups and clinical features and expression of 18 most valuable genes in LGG patients. G Analysis of differences in the expression of mtPCDI signature genes in two different subgroups. H Pathway activity between two different subgroups based on ssGSEA algorithm. *p < 0.05; **p < 0.01; ***p < 0.001; ns, no statistical significance