Table 3.
Stability and hydrolysis of A-series compounds
| Study | Buffer, pH | Reaction conditions (temperature, time) | Results |
|---|---|---|---|
| Harvey et al. (2020) | BTP, 7.2 | 25 °C, 10 min | A-230, A-232, and A-234 stable for 10 min |
| Lee et al. (2021) | AA (aq)a, 3.5 | n/a °C, 1 week | A-234 completely degraded after a week |
| DIW, 7.2 | n/a °C, 2 months | A-234 completely degraded after 2 months | |
| PC(aq)b, 9.4 | n/a °C, 2 months | A 234 remained stable after 2 months | |
| de Koning et al. (2022) | TBS, 4.5 | 25 °C, 30 h (A-230); 1 h (A-232, A-234) | A-230 completely degraded in 16 hA-232 and A-234 are stable for 60 min |
| TBS, 7 | 25 °C, 1 h | A-230, A-232, and A-234 stable for 60 min | |
| TBS, 10 | 25 °C, 1 h | A-230, A-232, and A-234 stable for 60 min | |
| Jacquet et al. (2021) | TBS, 9.5 | 25 °C, 1 h | A-230, A-232, and A-234 stable for 60 min |
| Jung et al. (2023) | DIW, 7.2 | 20–25 °C, 1 h | A-232 and A-234 stable for 60 min |
| HCl, 1 | 30 min | A-232 and A-234 completely degraded | |
| NaOH, 13 | 30 min | A-232 and A-234 completely degraded |
BTP BIS–TRIS propane, TBS TRIS-buffered saline, DIW deionized water, n/a not available
a0.01 M AA(aq), acetic acid aqueous solution
b0.01 M PC(aq), potassium carbonate aqueous solution