. 2023 Aug 24;97(10):2587–2607. doi: 10.1007/s00204-023-03571-8

Table 5.

Available data on the toxicity of the A-series agents

NAs	VX	A-230	A-232	A-234	A-242	A-262	Study
LD₅₀ (mg·kg^–1)	0.14	n/a	0.01–0.03	0.07	n/a	n/a	Karev (2009)^a
	0.09–0.14	0.1–0.03	0.5	0.5	n/a	n/a	Ellison (2017)^b
	10	n/a	1–2	5	n/a	n/a	Nepovimova and Kuca (2018)^c
	0.1	0.01–0.03	0.5	0.5	n/a	n/a	Franca et al. (2019)^c
	0.10	1.55	0.57	0.71	0.49	7.35	Carlsen (2019)^d
	n/a	0.50	0.41	0.63	9.02	22.85	Noga et al. (2023b)^d
	n/a	0.35	0.21	0.58	14.97	44.56	Noga et al. (2023b)^e
LCt₅₀ (mg·min·m^–3)	50	n/a	6–10	7	n/a	n/a	Nepovimova and Kuca (2018)^c
LCt₅₀ (mg·min·m^–3)	15	2–3	7	7	n/a	n/a	Franca et al. (2019)^c

n/a not available

^aAccording to Russian literature (did not specify sources)

^bUnknown source

^cUsed Karev’s and Ellison’s data

^dQSAR Toolbox, quantitative structure–activity relationship

^eTEST Consensus method, Toxicity Estimation Software Tool