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. 2023 Sep 2;14:5355. doi: 10.1038/s41467-023-41121-z

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© The Author(s) 2023

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/.

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Fig. 6 — a Illustration the mechanism of GPX4-related ferroptosis induced by COF-818 and COF-919. b Western blot results of representative pyroptosis factors, including GPX4, TFRC, and xCT in 4T1 cells treated under different conditions. Quantitative evaluation of the changes in cellular iron concentration (c) and GSH/GSSG ratio (d), treated under different conditions; data are presented as mean ± SEM (n = 3 independent samples). e Confocal fluorescence images of 4T1 cells, where the green fluorescence was attributed to BODIPY 581/591-C11 staining of lipid peroxidation; the photographs of immunofluorescence staining were representative of those generated from three independent samples with similar results. f Bio-TEM images of mitochondria in normal cells or that of COF-919 treatment; the photographs of TEM were representative of those generated from three independent samples with similar results. Statistical significance was calculated via one-way ANOVA with Tukey’s multiple comparisons test. Source data are provided as a Source Data file.