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. 2023 Sep 2;14:5354. doi: 10.1038/s41467-023-40893-8

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© The Author(s) 2023

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/.

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Fig. 6 — a UMAP plot of all single cells colored by cell type and time point in developing pancreatic endocrine cells. b Bar plot showing the percentage of each cell type in developing pancreatic endocrine cells. c Dot plot showing key marker gene expression in each cell type of developing pancreatic endocrine cells. d Heatmap showing the scaled activity of the top 5 highly scored regulons in each cell type of developing pancreatic endocrine cells. e RNA velocity plot showing the developmental trajectory of developing pancreatic endocrine cells. f UMAP plot showing the developmental trajectories of developing pancreatic endocrine cells. g Heatmap showing gene expression along the developmental trajectory of EP early to EP late cells. TFs are labeled on the right. h Selected enriched GO terms of genes in Fig. 6g. P-values were calculated by using enrichGO function from R package clusterProfiler with one-sided hypergeometric test. i Model of EP and endocrine cell differentiation. See also Supplementary Fig. 7 and Supplementary Data 5, 6.