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. 2023 Sep 2;14:5345. doi: 10.1038/s41467-023-40878-7

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© This is a U.S. Government work and not under copyright protection in the US; foreign copyright protection may apply 2023

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Fig. 5 — a Immunization and blood draw scheme for rats. The figure was created with BioRender.com. b Serum IgG titers against AMA1 DI-DII from three independent biological replicates. The dashed line indicates the detection limit of the assay, and the bars represent the geometric mean titers (GMTs). c Serum antibody titers blocking the AMA1 DI-DII/RON2L interaction from two independent biological replicates depicted as described in (b). d In vitro GIA of purified IgG from individual rats from each group at day 63 was tested at 5.0 mg/ml against Plasmodium falciparum 3D7 blood stage in three independent assays. Bars represent the median. The dashed line indicates the median of the adjuvant only group. Statistical comparisons and P values for (b), (c), and (d) were obtained using a Kruskal‒Wallis analysis followed by Dunn’s test to correct for multiple comparisons of the AMA1 DI-DII, immunogens and adjuvant only groups with the AMA1 DI-DII-RON2L complex group. Source data are provided as a Source data file.