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. Author manuscript; available in PMC: 2024 Apr 25.
Published in final edited form as: Mol Psychiatry. 2023 Mar 3;28(12):5128–5139. doi: 10.1038/s41380-023-02002-5

Figure 4. Differential time courses of fMRI-BOLD activation to negative faces minus neutral faces.

Figure 4.

The percent MR signal change (mean ± sem) from baseline to negative minus neutral faces within regions of interest. Participants were divided into an earlier exposure group who reported exposure to any of the significant early regionally-specific risk factors associated with an attenuated response (but not any of the significant later exposure risk factors), a later exposure group who reported exposure to any of the significant later regionally-specific risk factors associated with an enhanced response (but not any of the significant early exposure risk factors), and unexposed group who reported no exposure to any of the significant early or later type/time risk factors. The graph extends for the duration of each fMRI trial block and presents the mean of the differences in degree of BOLD activation to threatening versus neutral faces at each MRI pulse sequence repetition time.