Table 2.

10 published abstracts of dosimetric studies of CBCT-guided ART

Disease site	Article	Number of Patients	Adapted Fractions Evaluated	Online ART procedural time	Outcomes
Bladder	Azzarouali et al. [43]	5	–	Median 32 min	Improved PTV coverage with adaptive planning
Bladder	Storm et al. [44]	17	132	Median 14 min	Intra-fractional variations during online ART of bladder cancer were limited, which may be explained by a strict bladder filling regimen
Bladder	Zwart et al. [61]	3	–	–	Adapted plan coverage was ≥ 99% for all sessions, compared to only 2/73 session reached this level for scheduled plans
Bony Metastases (Lumbar and Thoracic Spine, and Pelvis)	Nelissen et al. [57]	8	–	Average 36 min	Patients were satisfied with the procedure and completed consultation and treatment within two hours
Brain	Kang et al. [49]	7	–	Average 44.2 min*	Adaptation improved target coverage and limited hotspots in the hippocampal avoidance zone
Breast	Stanley et al. [58]	2	–	–	Daily adaptive replanning shows potential for reduced PTV margins and reduced OAR doses
Head and Neck	Dohopolski et al. [60]	10	–	–	Adapted planning significantly improved median V100% coverage, homogeneity, and total median dose reduction in OARs
Lung	Gonzalez et al. [46]	18	68	Average 15 min	Significant improved target coverage, dose conformity, and OAR sparing with online adaptive planning
Lower lung and Upper Abdomen	Kim et al. [50]	8	36	Average 27 min	CBCT-guide ART demonstrated inter- and intra-fractional motion Residual motion of tumor was comparable to that of the imaging-surrogate within clinical PTV margins (5 mm) but a bit larger than the pre-configured gating window
Liver, Pelvis, Abdomen, and Lung	Musunuru et al. [62]	15	–	–	Adapted plans had superior coverage, and nearly always met OAR tolerances compared to scheduled plans

*The initial adaptation is from a plan generated from a diagnostic image, not a sim CT