Table 1.

Summary of Studies on the Effect of CoQ10 on Ovarian Aging

Methods	Animal Species	CoQ10	Number	Age Mean or Range	Duration	Outcomes	References
Animal experiment	PDSS2 gene knockout mice	22mg/kg, Injection Sigma-Aldrich or Advanced Orthomolecular Research Inc., Calgary, Alberta, Canada	12	9months	13weeks	Increased oocyte quality and number of ATP Reduced level of ROS	[51]
	Sprague–Dawley rats	150mg/kg, Oral Gfn-Selco, Germany	8 Cisplatin treatment	65–75days	2weeks	Increased level of AMH Reduced number of atresia follicles	[62]
	C57BL/6 mice	0.084mg/kg, Injection Sigma Aldrich, St. Louis, MO, USA	8	9months	12weeks	Increased glucose intake, number of GCs restoration of mitochondrial function	[52]
	NMRI mice	22mg/kg, Injection Sigma‐Aldrich, Germany	8 CTX treatment	8–10weeks	3weeks	Increased IVF success rates and development of embryo Reduced level of ROS and number of atresia follicles	[61]
	C57BL/6 mice	150mg/kg, Oral Sigma Aldrich, St. Louis, MO, USA	10 VCD treatment	6weeks	2weeks	Increased level of AMH Reduced level of ROS	[63]
		150mg/kg, Oral Sigma Aldrich, St. Louis, MO, USA	32 VCD treatment	6weeks	2weeks	Increased oocyte quality and development of embryo
Clinical trial	–	200mg/d, Oral Myoquinone, Pharmanord, Copenhagen, Denmark	15	31–46years	30–35days	Increased oocyte quality and antioxidant capacity of follicular fluid	[72]
	–	50μmol/L, IVM MW 863.34, Sigma	45	38–46years	24h	Increased oocyte maturation rates Reduced postmeiotic aneuploidies	[54]

Abbreviations: CoQ10, coenzyme Q10; ATP, adenosine triphosphate; ROS, reactive oxygen species; AMH, anti-millerian hormone; CTX, cyclophosphamide; IVF, in vitro fertilization; VCD, 4-vinylcyclohexene diepoxide; IVM, in vitro maturation; GCs, granulosa cells.