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. 2023 Aug 6;14(13):2481–2490. doi: 10.7150/jca.84537

Figure 4.

Figure 4

Tan IIA dose-dependently inhibited the tumor growth of OSCC cells in vivo. (A-C) The tumor volume (A), The image of tumor mass (B), and tumor weight (C) of CAL27-derived xenograft tumors treated with vehicle, low, and high Tan IIA. (D) The body weight of tumor-bearing mice with the vehicle, low, and high Tan IIA treatment. (E and F) IHC staining of Ki67 and PUMA in CAL27-derived xenograft tumors with the vehicle, low, and high Tan IIA treatment. (G) HE staining analysis of the heart, liver, spleen, lung, and kidney in vehicle- or Tan IIA-treated xenograft tumors. Scale bar, 25 μM, **, p < 0.01, ***, p < 0.001.