表 3. Potential salivary biomarkers for pancreatic cancer.
潜在的胰腺癌唾液标志物
| Category | Salivary tumor biomarkers | Sensitivity | Specificity | Expression | References |
| KRAS: Kirsten rat sarcoma viral oncogene homolog; MBD3L2: methyl-CpG binding domain protein 3 like 2; ACRV1: acrosomal vesicle protein 1; DPM1: dolichol-phosphate mannosyltransferase subunit 1; CEA: carcinoembryonic antigen; CA: cancer antigen. | |||||
| mRNA | KRAS, MBD3L2, and ACRV1 | 90.0% | 95.0% | ↑ | [33] |
| DPM1 | 90.0% | 95.0% | ↓ | [33] | |
| miRNA | miR-17, miR-21, miR-181a, miR-181b, and miR-196a | — | — | ↑ | [38] |
| hsa-miR-21 | 71.4% | 100% | ↑ | [34] | |
| hsa-miR-23a | 85.7% | 100% | ↑ | [34] | |
| hsa-miR-23b | 85.7% | 100% | ↑ | [34] | |
| miR-29c | 57% | 100% | ↑ | [34] | |
| Protein | CEA and CA125 | 92.31% | 84.62% | ↑ | [32] |
| Microorganism | Neisseria elongata and Streptococcus mitis | 96.4% | 82.1% | ↓ | [35] |