表 4. Potential salivary biomarkers for breast cancer.
潜在的乳腺癌唾液标志物
| Category | Salivary tumor biomarkers | Sensitivity | Specificity | Expression | References |
| CSTA: cysteine protease inhibitor A; TPT1: translationally-controlled tumor protein 1; IGF2BP1: insulin-like growth factor 2 mRNA-binding protein 1; GRM1: metabotropic glutamate receptor 1; GRIK1: glutamate receptor, ionotropic, kainate 1; H6PD: hexose-6-phosphate dehydrogenase; MDM4: murine double minute 4; S100A8: S100 calcium-binding protein A8; CA: cancer antigen; ER-α: estrogen receptor-alpha; VEGF: vascular endothelial growth factor; EGF: epidermal growth factor; CEA: carcinoembryonic antigen; HER2: human epidermal receptor 2. | |||||
| mRNA | CSTA, TPT1, IGF2BP1, GRM1, GRIK1, H6PD, MDM4, and S100A8 | 83% | 97% | ↑ | [46] |
| Protein | CA6 | — | — | ↑ | [1] |
| CA15-3 | 95.87% | 88.66% | ↑ | [48] | |
| ER-α, VEGF, EGF, CEA, HER2, CA15-3, P53, and CA125 | — | — | ↑ | [4] | |
| Small molecule | Choline, isethionate, cadavarine, N1-acetylspermidine, and spermine |
— | — | ↑ | [1] |