TABLE 1.

Measurement schedule.

Time points	Baseline	Before study drug	Study drug intervention							Day after study drug ended	Discharged from hospital
			Day1 (per 4 h)	Day2 (per 4 h)	Day3 (per 4 h)	Day4 (per 4 h)	Day5 (per 4 h)	Day6 (per 4 h)	Day7 (per 4 h)
Informed consent	×
Inclusion/Exclusion criteria	×
Demographic characteristics	×
Medical History	×
APACHE II	×
SOFA	×
Blood test		×								×
Blood biochemistry		×								×
Cytokines		×								×
Blood coagulation		×								×
Cardiac LVEF		×								×
Remifentanil		×
CPOT		×
CAM-ICU		×
RASS		×	×	×	×	×	×	×	×
Dextrmetomidine (Yes/No)			×	×	×	×	×	×	×
Adverse reactions			×	×	×	×	×	×	×
ICU-stay time											×
Ventis											×
Hospital costs											×
28-day mortality											×