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. 2023 Aug 21;14:1221609. doi: 10.3389/fimmu.2023.1221609

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Copyright © 2023 Song, Zeng, Cao, Zhang, Xu, Pan, Zhao and Liu

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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The effects of METTL3 and m6A reader proteins mentioned in this review on RNA modification and metabolism. Figure Legends: METTL3 adds the m6A motif to RNA. HNRNPA2B1 recognizes m6A in the nucleus and promotes miRNA maturation. IGF2BP1/2 recognizes m6A in the nucleus and promotes mRNA stability. YTHDF1 recognizes m6A in the cytoplasm and enhances mRNA translation. YTHDF2 recognizes m6A in the cytoplasm and promotes mRNA decay.