Table 3.
Effects of natural products, synthetic compounds, and biological agents on METTL3.
| Category | Examples | Effect | In vivo | In vitro | Ref |
|---|---|---|---|---|---|
| Natural Products | Emodin | Upregulation of METTL3 | – | LPS-treated 1321N1 cells | (144) |
| Cinnamaldehyde | Upregulation of METTL3 | – | Free fatty acids induced AML12 | (145) | |
| Total flavones of Abelmoschus manihot | Upregulation of METTL3 | – | High glucose treated MPC-5 cells | (80) | |
| Resveratrol | Downregulation of METTL3 | Mice fed with high-fat diet | – | (146) | |
| Resveratrol | Upregulation of METTL3 | Mice fed with high-fat diet | – | (147) | |
| Synthetic compounds | Cpd-564 | Downregulation of METTL3 | Cisplatin- and I/R-induced AKI mouse model | Cisplatin-treated HK2 cells | (78) |
| S-adenosylhomocysteine (SAH) | Downregulation of METTL3 | Monosodium iodoacetate induced TMJ OA mice | TNF-α induced chondrocytes | (84) | |
| Methylation inhibitor cycloleucine | No effects | Collagenase-induced OA mice | – | (82) | |
| Methyl donor betaine | No effects | Collagenase-induced OA mice | – | (82) | |
| Biological agents | miR-1208 within hucMSCs-EVs | Downregulation of METTL3 | DMM-induced OA knee mice model | LPS and nigericin-treated THP-1 | (148) |