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Diagram of NF‐kB signaling pathway in knee osteoarthritis. The pathway diagram showed that IL‐1β, TNF‐α, and other factors could mediate signal expression as initiators of NF‐kB signaling pathway. TRAF6 and TAK1 are NF‐κB pathway hub factors, which ultimately lead to the expression of inflammatory factors such as IL‐8, IL‐1β, TNF‐α, A20, COX‐2, and MIP‐1β, leading to increased inflammation and ECM degradation.
