Table 4. rs1047972 and rs8173 variants of the AURKA gene and their association with the breast cancer group.
Variant | Genotype | Variable | OR (95% CI) | p-value |
---|---|---|---|---|
rs1047972 | CT | Overweight | 2.6 (1.26–5.67) | 0.010 |
CTTT | 2.3 (1.17–4.46) | 0.016 | ||
CT | Obesity | 3.2 (1.60–6.66) | 0.001 | |
CTTT | 2.5 (1.32–4.87) | 0.005 | ||
CTTT | Family history of cancer | 1.9 (1.03–3.68) | 0.038 | |
CTTT | Estrogen receptor plus obesity | 2.5 (1.11–5.79) | 0.027 | |
CTTT | Ki-67 (≥ 20%) plus family history of cancer | 2.66 (1.14–6.2) | 0.023 | |
rs8173 | CG | Chemotherapy gastric toxicity | 1.6 (1.05–2.46) | 0.029 |
CGGG | 1.7 (1.11–2.72) | 0.015 | ||
CGGG | Estrogen receptor plus chemotherapy gastric toxicity | 2.0 (1.15–3.48) | 0.013 | |
CGGG | Progesterone receptor plus chemotherapy gastric toxicity | 2.6 (1.42–4.9) | 0.002 | |
CGGG | Menopause plus chemotherapy gastric toxicity | 2.0 (1.15–3.7) | 0.014 |
p-value less than 0.05 considered statistically significant.
OR = odds ratio; CI =confidence intervals.