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Mutations reported in the literature. (A) Number of mutations affecting the coding sequence classified according to their effect on the protein. (B) Frequency of single nucleotide substitutions. (C) Boxplot representation of mutations observed in the coding sequence of TETs in the upper representation and in each single patients in the lower representation. (D) Mutational signatures enriched in TETs. (E) Most frequently mutated genes in TETs and type of mutation observed.
