Table 2.
Echocardiographic parameters and repolarization indexes initial and after ranolazine treatment.
| Variables | CSF | Control group | ||||
|---|---|---|---|---|---|---|
| Baseline | Follow- up | p-value | Baseline | Follow- up | p-value | |
| IVRT | 87.85 ± 18.67 | 82.24 ± 17.77 | 0.005 | 78.21± 9.86 | 78.52 ± 9.13 | 0.734 |
| E′ | 73.21 ± 16.86 | 75.66 ± 14.62 | 0.269 | 75.33 ± 14.71 | 75.17 ± 15.26 | 0.798 |
| A′ | 77.98 ± 20.83 | 79.37 ± 17.12 | 0.459a | 76.37 ± 14.22 | 76.49 ± 14.98 | 0.859 |
| E′/A′ | 0.96 ± 0.28 | 0.98 ± 0.29 | 0.543 | 1.02 ± 0.26 | 1.02 ± 0.29 | 0.802 |
| DT | 201.22 ± 34.16 | 189.59 ± 26.13 | <0.001 | 206.90 ± 27.62 | 204.45 ± 30.47 | 0.338 |
| E mean | 8.22 ± 1.42 | 8.49 ± 1.24 | 0.004 | 8.40 ± 1.37 | 8.46 ± 1.29 | 0.345 |
| A mean | 10.64 ± 2.89 | 10.88 ± 2.50 | 0.068 | 10.59 ± 2.30 | 10.56 ± 2.28 | 0.666 |
| Em/Am ratio | 0.82 ± 0.27 | 0.90 ± 0.34 | 0.008 | 0.87 ± 0.27 | 0.89 ± 0.28 | 0.334 |
| E/e′ | 9.18 ± 2.34 | 9.08 ± 2.18 | 0.733 | 8.88 ± 2.36 | 9.01 ± 2.18 | 0.740 |
| Heart Rate, bpm | 75.80 ± 12.60 | 73.68 ± 10.56 | 0.204 | 76.24 ± 12.72 | 74.56 ± 13.24 | 0.145 |
| QT | 376.76 ± 20.92 | 386.28 ± 26.27 | 0.037 | 371.31 ± 20.19 | 375.31 ± 21.21 | 0.014 |
| Cor. P disp. | 40.90 ± 10.13 | 32.23 ± 8.16 | 0.009 | 37.40 ± 7.89 | 35.26 ± 8.08 | 0.107 |
| Cor. QT disp | 41.63 ± 7.72 | 40.31± 7.01 | 0.196 | 36.49 ± 9.23 | 37.04 ± 8.97 | 0.145 |
| Cor. Tp-e interval | 81.52 ± 12.92 | 76.14 ± 7.77 | 0.008 | 76.06 ± 8.69 | 75.21 ± 8.69 | 0.631 |
| cQT | 421.47 ± 35.26 | 426.30 ± 26.09 | 0.337 | 420.75 ± 31.73 | 418.66 ± 30.38 | 0.485 |
| Tp-E interval | 376.76 ± 20.92 | 386.28 ± 26.27 | 0.037 | 371.31 ± 20.19 | 375.31 ± 21.21 | 0.014a |
| Tp-E/QT | 0.19 ± 0.02 | 0.17 ± 0.03 | 0.315 | 0.16 ± 0.02 | 0.16 ± 0.02 | 0.588 |
| Tp-E/cQT | 0.17 ± 0.02 | 0.17 ± 0.02 | 0.944 | 0.17± 0.02 | 0.17 ± 0.02 | 0.851 |
| RR interval | 0.81 ± 0.12 | 0.83 ± 0.12 | 0.431 | 0.82 ± 0.14 | 0.83 ± 0.14 | 0.009 |
Data are presented as mean ± SD.
Parametric dependent samples were evaluated by paired samples T test.
A, mitral inflow contraction velocity; Am, atrial contraction wave using TDI; CDI, conventional Doppler imaging; DT, deceleration time; E, mitral velocity of early diastolic filling from transmitral flow; Em, early diastolic filling using TDI; Em/Am, diastolic myocardial motion velocities using TDI (early and late phase); IVRT, isovolumic relaxation time; TDI, tissue Doppler imaging; cPd, corrected P dispersion; cQT, corrected QT interval; cTp-e, corrected transmural dispersion of repolarization.
Friedman test was used for non-parametric dependent samples.