Table 3.

Study summaries showing the effects of ranolazine on diastolic functions and repolarization parameters.

Author	Year	Aim	Treatment modality	Number of patients	Trial parameters	Results
Maier et al. (24)	2013	Diastolic functions in patients with HfpEF Inclusion criteria were EF ≥45%	Treatment consisted of intravenous infusion for 24 h	Patients were randomized to ranolazine (n: 12) and placebo (n: 8).	E/e′ ratio Repolarization measures as QT Interval in ECG	Echocardiographic diastolic parameters were not changed significantly. Non-significant QT interval increase was seen in ranolazine group.
Figueredo et al. (2)	2011	Improvement In left ventricular systolic and diastolic performance in patients with stable angina	Initial treatment was 500 mg bid. After 1 week dose increased to 1,000 mg bid. The evaluation was. Done minimum after 30 days.	22 patients without control group.	Mitral valve inflow velocities, tissue Doppler velocities, mitral annular diastolic velocities, E′/A′ ratio, E/E′ ratio, isovolumic contraction and relaxation times, ejection time and myocardial performance index	DT, IVCT, IVRT, ET and MPI were improved on ranolazine therapy.
Akcay et al. (22)	2021	Effects On ECG repolarization parameters	Patients used 750 mg or 1,000 mg doses. No significant difference was observed between the groups.	175 patients 90 of the m received ranolazine 85 of them was in control group.	Tp-e, QT, QTc intervals, Tp-e/QT, and Tp-e/QTc ratios	Tp-e interval, Tp-e/QT, Tp-e/QTc and PWD were significantly lower in the ranolazine group.
Babalis et.al (18)	2014	Effects Of ranolazine on left ventricular diastolic function in chronic coronart disease	Patients in ranolazine group used 500 mg bid ranolazine for 3 months.	40 pts; 20 in control group, 20 in ranolazine group	Mitral E velocity, mitral A velocity, E/A ratio, mitral anular e′ and a′ velocities, E/e′ ratio, DT, IVRT	Mitral E velocity, mitral A velocity, E/A ratio, e′, a′, E/e′, DT and IVRT significantly improved on ranolazine group.