TABLE 1.

Combination index (CI) of the colony formation assay.

	Dose chemo (nM)	Dose radiation (Gy)	Dose virus (VP/cell)	Effect	CI
C + R	2.5	0.625	–	0.754	12.79
	2.5	1.25	–	0.599	0.9563
	2.5	2.50	–	0.422	0.5115
R + V	–	0.625	0.0625	0.562	0.4464
	–	0.625	0.300	0.170	0.3971
	–	0.625	0.625	0.150	0.7211
C + V	2.5	–	0.0625	0.631	1.102
	2.5	–	0.300	0.219	0.8981
	2.5	–	0.625	0.139	1.006
C + R + V	2.5	0.625	0.0625	0.506	0.8775
	2.5	0.625	0.300	0.121	0.6047
	2.5	0.625	0.625	0.063	0.5917

Note: Calculation of the combination index (CI) to determine synergism (CI < 1), antagonism (CI > 1), or additive effect (CI = 1) between virus, chemotherapy, and radiation was performed using Compusyn software.

Abbreviations: C + R + V, chemotherapy + radiation + IFN‐OAd; C + R, chemotherapy + radiation; C + V, chemotherapy + IFN‐OAd; R + V, radiation + IFN‐OAd.