TABLE 1.
Clinical characteristics of patients with Langerhans cell histiocytosis at diagnosis (n = 148).
| Characteristics | Data |
|---|---|
| Sex, n (%) | |
| Male | 90 (60.8) |
| Female | 58 (39.2) |
| Median age at diagnosis, year (range) | 46.5 (20–87) |
| Mean time for diagnosis, months (range) | 15 (0–378) |
| Initial manifestation, n (%) | |
| Local pain | 56 (37.8) |
| Abnormal findings on images | 24 (16.2) |
| Palpable mass | 22 (14.9) |
| Rash | 21 (14.2) |
| Respiratory symptoms | 17 (11.5) |
| Palpable lymph nodes | 10 (6.8) |
| Diabetes insipidus | 6 (4.1) |
| Fever | 6 (4.1) |
| Other | 8 (5.4) |
| Department on first admission, n (%) | |
| Respiratory | 33 (22.3) |
| Orthopedics | 33 (22.3) |
| Dermatology | 19 (12.8) |
| Neurosurgery/Neurology | 14 (9.5) |
| Hematology | 11 (7.4) |
| Endocrinology | 7 (4.7) |
| Oral surgery | 5 (3.4) |
| General internal medicine | 5 (3.4) |
| Gastroenterology | 4 (2.7) |
| Surgery | 4 (2.7) |
| Otorhinolaryngology | 4 (2.7) |
| Other | 9 (6.1) |
| Histological diagnoses, n (%) | |
| Bone | 57 (38.5) |
| Lung | 29 (19.6) |
| Skin | 27 (18.2) |
| Lymph node | 13 (8.8) |
| Soft tissue | 5 (3.4) |
| Liver | 4 (2.7) |
| Pituitary gland/CNS | 3 (2.0) |
| Thyroid gland | 3 (2.0) |
| Other | 7 (4.7) |
Abbreviation: CNS, central nervous system.