TABLE 5.
Univariate and multivariate analyses for overall survival of patients with Langerhans cell histiocytosis.
| Number of patients | Univariate analysis | Multivariate analysis | |||
|---|---|---|---|---|---|
| p‐values | Hazard ratio (95% CI) | p‐values | |||
| Age, years | ≥60 | 19 | 0.0017 | 6.21 (1.12–34.61) | 0.037 |
| <60 | 67 | 1 | |||
| Sex | Male | 49 | 0.64 | ||
| Female | 37 | ||||
| Bone involvement | Yes | 52 | 0.92 | ||
| No | 34 | ||||
| Lung involvement | Yes | 24 | 0.78 | ||
| No | 62 | ||||
| Pituitary gland involvement | Yes | 22 | 0.66 | ||
| No | 64 | ||||
| Lymph node involvement | Yes | 21 | 0.011 | 3.87 (0.69–21.84) | 0.125 |
| No | 65 | 1 | |||
| Skin involvement | Yes | 20 | 0.17 | ||
| No | 66 | ||||
| CNS involvement | Yes | 13 | 0.96 | ||
| No | 73 | ||||
| Risk organ a involvement | Yes | 17 | 0.0034 | 4.56 (0.80–26.01) | 0.087 |
| No | 69 | 1 | |||
| Special site b involvement | Yes | 22 | 0.47 | ||
| No | 64 | ||||
Abbreviation: CNS, central nervous system (excluding the pituitary gland).
a
Risk organs: liver, spleen, or hematopoietic system.
b
Special sites: vertebral lesions with intraspinal or craniofacial bone lesions with soft tissue extensions (orbit, mastoid, sphenoid, or temporal bones).