Table 3.
Clinical Outcomes: VC Compared With VPT
| Variable | VC (n = 6,371) | VPT (n = 6,371) | OR |
|---|---|---|---|
| KDIGO AKI stage | |||
| 1 | 423 (6.6) | 455 (7.1) | . . . |
| 2 | 206 (3.2) | 322 (5.1) | . . . |
| 3 | 762 (12.0) | 935 (14.7) | . . . |
| 2/3 | 968 (15.2) | 1,257 (19.7) | 1.37 (1.25-1.49) |
| AKI requiring dialysis | 503 (7.9) | 633 (9.9) | 1.28 (1.14-1.45) |
| Dialysis or in-hospital mortality | 1,254 (19.7) | 1,383 (21.7) | 1.14 (1.04-1.23) |
| In-hospital mortality | 894 (14.0) | 936 (14.7) | 1.05 (0.95-1.16) |
| Hospital length of stay, d | 10.9 ± 10.3 | 10.6 ± 7.9 | . . . |
| Hospital discharge location | |||
| Death | 894 (14.0) | 936 (14.7) | . . . |
| Home | 2,663 (41.8) | 2,779 (43.6) | . . . |
| Nursing home | 368 (5.8) | 346 (5.4) | . . . |
| Other | 145 (2.3) | 145 (2.3) | . . . |
| External | 472 (7.4) | 487 (7.6) | . . . |
| Hospital | 272 (4.3) | 307 (4.8) | . . . |
| Skilled nursing facility | 1,557 (24.4) | 1,371 (21.5) | . . . |
Data are presented as No. (%) or mean ± SD, unless otherwise indicated. AKI = acute kidney injury; KDIGO = Kidney Disease: Improving Global Outcomes; VC = vancomycin and cefepime; VPT = vancomycin and piperacillin-tazobactam.