Methylated indole derivatives with inhibitory activities (IC₅₀) against AChE and BuChE and antioxidant activity^a.

Compound	R	IC50 ± SE (μM)			% free radicle scavenging, mean ± SE (μM)
		hAChE	hBuChE	Selectivity ratio	50	100
IND-24	–3OH	12.54 ± 0.143	98.18 ± 0.120	7.83	17.68 ± 0.478	34.34 ± 1.333
IND-25	–3OCH3	264.23 ± 0.102	>1000	3.78	11.51 ± 0.748	27.99 ± 1.127
IND-30	–4OH	4.16 ± 0.063	95.34 ± 0.144	22.92	15.19 ± 0.881	30.65 ± 1.010
IND-31	–2OCH3	421.22 ± 0.086	>1000	2.37	9.75 ± 0.625	26.43 ± 0.887
IND-40	–2,6OH	70.54 ± 0.133	689.12 ± 0.128	9.77	24.10 ± 0.889	50.39 ± 0.930
IND-42	–2,3OH	122.75 ± 0.086	668.22 ± 0.133	5.44	18.21 ± 0.598	38.87 ± 1.012
DNP	—	0.03 ± 0.022	01.41 ± 0.084	—	—	—
Ascorbic acid	—	—	—	—	42.66 ± 1.491	76.76 ± 0.708

^aSelectivity ratio = (IC₅₀ of BuChE)/(IC₅₀ ofAChE).