Table 2.
Analysis of the association between expression of HSP60 and survivin protein and clinicopathological features of oral squamous cell carcinoma (OSCC) (n = 79)
| Clinicopathological | HSP60 | Survivin | ||||
|---|---|---|---|---|---|---|
| features (n) | High (%) | Low (%) | P | High (%) | Low (%) | P |
| Age | ||||||
| < 50 years(n = 29) | 14(48.3) | 15(51.7) | 15(51.7) | 14(48.3) | ||
| ≥ 50 years(n = 50) | 34(68.0) | 16(48.4) | 0.084 | 33(66.0) | 17(34.0) | 0.239 |
| Gender | ||||||
| Male(n = 64) | 39(60.9) | 25(39.1) | 39(60.9) | 25(39.1) | ||
| Female(n = 15) | 9(60.0) | 6(40.0) | 1.000 | 9(60.0) | 6(40.0) | 1.000 |
| Cigarette | ||||||
| Yes(n = 48) | 31(64.6) | 17(35.4) | 29(60.4) | 19(39.6) | ||
| No(n = 31) | 17(54.8) | 14(45.2) | 0.480 | 19(61.3) | 12(38.7) | 1.000 |
| Alcohol | ||||||
| Yes(n = 41) | 25(61.0) | 16(39.0) | 24(58.5) | 17(41.5) | ||
| No(n = 38) | 23(60.5) | 15(39.5) | 1.000 | 24(63.2) | 14(36.8) | 0.818 |
| Areca nut | ||||||
| Yes(n = 34) | 18(52.9) | 16(47.1) | 23(67.6) | 11(32.4) | ||
| No(n = 45) | 30(66.7) | 15(33.3) | 0.250 | 25(55.6) | 20(44.4) | 0.354 |
| Differentiation | ||||||
| Well(n = 58) | 33(56.9) | 25(43.1) | 38(65.5) | 20(34.5) | ||
| Moderate(n = 13) | 10(76.9) | 3(23.1) | 4(30.8) | 9(69.2) | ||
| Poor(n = 8) | 5(62.5) | 3(37.5) | 0.407 | 6(75.0) | 2(25.0) | 0.047* |
| Clinical stages | ||||||
| Stage I−II (n = 43) | 20(46.5) | 23(53.5) | 27(62.8) | 16(37.2) | ||
| Stage III−IV (n = 36) | 27(77.8) | 9(22.2) | 0.006* | 21(58.3) | 15(41.7) | 0.818 |
| LNM | ||||||
| LNM (n = 28) | 23(82.1) | 5(17.9) | 16(57.1) | 12(42.9) | ||
| No LNM (n = 51) | 37(49.0) | 13(51.0) | 0.004* | 32(62.7) | 19(37.3) | 0.639 |
| Survival status | ||||||
| Alive (n = 56) | 29(51.8) | 27(48.2) | 35(62.5) | 21(37.5) | ||
| Death (n = 23) | 19(82.6) | 4(17.4) | 0.012* | 13(56.5) | 10(43.5) | 0.623 |
*Chi-square test, statistically significant difference (P < 0.05)
Abbreviations: LNM, lymph node metastasis