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. 2023 Sep 4;23:307. doi: 10.1186/s12906-023-04129-y

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© The Author(s) 2023

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated in a credit line to the data.

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Fig. 2 — The effects of (A) AH, (B) BH, (C) EH, and (D) RH on the levels of histamine released by PMACI-induced HMC-1 cells. PMACI-induced cells were pre-treated without (normal control) or with increasing concentrations of KHs (0.25, 0.5, and 1%) for 1 h followed by 24 h induction with PMACI. The cromolyn sodium treatment group was used as a positive control. The level of cytokines released were determined using respective ELISA kits according to the manufacturer’s protocol. Results obtained from three repeated independent experiments are expressed as mean $\pm$ standard error of mean (SEM). ** P < 0.01 and *** P < 0.005 as compared to the normal control group (black bars)