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LncRNAs regulate adaptive immune cells. LncRNAs mediate CD8+ T cell exhaustion, apoptosis, infiltration, and cytotoxicity. In addition, lncRNAs control the ratio of Th1-to-Th2 cells and regulate Th cell differentiation. Furthermore, lncRNAs mediate the differentiation, distribution, and immune evasion of Tregs. Additionally, lncRNAs regulate B-cell proliferation and apoptosis.
