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The combination of Que and 5-FU attenuated the Nrf2 and HO-1 expression in CC cells and 5-FU-resistant CC cells. After the cells were treated with 5-FU, Que, or Que plus 5-FU, immunofluorescence assay was used to examine the expression of nuclear factor erythroid 2-related factor (Nrf2) and heme oxygenase-1 (HO-1) in CC cells (A) and 5-FU-resistant CC cells (B). n=3. Que: quercetin; 5- FU: 5-fluorouracil, CC: colon cancer. ▲▲P<0.01 vs control; ##P<0.01 vs 5-FU.
