Table 1.
Characteristics of included studies
| Study, country | Year | Study period | Source population | IBD cohort (n) | Mean age at inclusion (yr) | Reference cohort (n) | Reported relative risk estimate (95% CI) | Overall incidence (%) and incidence rate (per 100,000 pyrs) of cervical cancer | Adjusted variables | NOS study qualitya | ||||||
| Overall IBD | CD | UC | IBD | CD | UC | Estimate type | Patients with IBD | Non-IBD patients | ||||||||
| Bernstein et al., Canada (24) | 2001 | 1998–1997 | Patients in the Manitoba region of Canada | 5,529 | 2,857 | 2,672 | 38.9 | 55,290 | 0.91 (0.28, 2.97) | Not reported | Not reported | IRR | 0.054% 13.5 per 100,000 pyrs |
Not reported | Age, area of residence, and time period | 9 |
| Goetgebuer et al., Netherlands (25) | 2021 | 2000–2016 | Patients in the Netherlands identified from Dutch nationwide IBD bank | 2,098 | 1,382 | 716 | 42 | 8,392 | 1.46 (1.07, 2.00) | Not reported | Not reported | HR | 0.095% 8.55 per 100,000 pyrs |
0.083% 7.50 per 100,000 pyrs |
Age and year of record | 7 |
| Goldacre et al., UK (26) | 2008 | 1963–1999 | Patients from the Oxford region of the United Kingdom | 12,117 | 5,127 | 6,990 | 45.2 | 457,071 | 2.30 (1.27, 4.15) | 2.63 (1.12, 5.29) | 1.91 (0.69, 4.24) | RR | 0.15% 3.21 per 100,000 pyrs |
0.052% (expected incidence) 1.44 per 100,000 pyrs (expected) |
Age, date of earliest record, and urbanization level | 8 |
| Hemminki et al., Sweden (27) | 2012 | 1964–2008 | Patients in Sweden identified from a national hospital discharge register | 27,158 | 12,886 | 14,272 | Not reported | [calculated expected number of cases] | 0.94 (0.71, 1.23) | 0.89 (0.58, 1.31) | 0.98 (0.67, 1.40) | SIR | 0.21% CD: 6.63 per 100,000 pyrs UC: 6.37 per 100,000 pyrs |
Not reported | Age groups, time period, region, and socioeconomic status | 7 |
| Rungoe et al., Denmark (28) | 2015 | 1979–2011 | Patient in Denmark identified from a national register | 27,408 | 8,717 | 18,691 | 44.5 | 1,508,334 | 1.03 (1.08, 0.82) | 1.53 (1.04, 2.27) | 0.78 (0.53, 1.13) | IRR | 0.20% 6.16 per 100,000 pyrs |
0.20% 5.92 per 100,000 pyrs |
Age, area of residence, and time period; no history of IBD or hysterectomy | 9 |
a
Maximum score = 9.
CD, Crohn's disease; CI, confidence interval; ERR, expected rate ratio; HR, hazard ratio; IBD, inflammatory bowel disease; IRR, incidence rate ratio; NOS, Newcastle-Ottawa Scale; pyrs, person years; SIR, standardized incidence rate; UC, ulcerative colitis.