Table 1.

Details of the studies enrolled in this systematic review.

Study	Year	Confirmed cases	Study title	Summary	References
Ongoina et al	2017–2018	40	Clinical course and outcome of human monkeypox in Nigeria	Headache 19, myalgia 25, seizure 1, encephalitis 3, photophobia 9	[9]
Ongoina et al	2017	18	The 2017 human monkeypox outbreak in Nigeria – report of outbreak experience and response in the Niger Delta University Teaching Hospital, Bayelsa State, Nigeria	Headache 12, myalgia 5, photophobia 3	[20]
Yinka et al	2017–2018	118	Outbreak of human monkeypox in Nigeria in 2017–18: a clinical and epidemiological report	Headache 61, myalgia 42, photophobia 27	[21]
Akar et al	2017–2019	165	Descriptive epidemiology of monkeypox in Nigera, September 2017–June 2019	Headache 78	[22]
Eseigbe et al	2018	2	Human monkey pox virus infection in Plateau State, north central Nigeria: a report of 2 cases	Headache 2	[7]
Hughes et al	2009–2014	134	A tale of 2 viruses: coinfections of monkeypox and varicella zoster virus in the Democratic Republic of Congo.	Headache 99, myalgia 90, fatigue 115	[23]
Pittman et al	2007–2011	216	Clinical characterization of human monkeypox infections in the Democratic Republic of the Congo	Headache 49, myalgia 15, dizziness 3, visual deficit 5, fatigue 11	[24]
Ježek et al	1980–1985	282	Human monkeypox: clinical features of 282 patients	Encephalitis 1, coma 1	[8]
Huhn et al	2003	34	Clinical characteristics of human monkeypox, and risk factors for severe disease	Headache 13, myalgia 19, seizure 1, encephalitis 1	[10]
Croft et al	2003	19	Occupational risks during a monkeypox outbreak, Wisconsin, 2003	Headache 13	[25]
Reed et al	2003	11	The detection of monkeypox in humans in the Western Hemisphere	Headache 11, myalgia 1	[26]
Reynolds et al	2003	37	Clinical manifestations of human monkeypox influenced by route of infection	Headache 32, myalgia 36	[27]
Anderson et al	2003	1	A case of severe monkeypox virus disease in an American child: emerging infections and changing professional values	Headache 1, myalgia 1, fatigue 1	[28]
Sejvar et al	2003	3	Human monkeypox infection: a family cluster in the Midwestern United States	Headache 2, seizure 1, encephalopathy 1, encephalitis 1	[11]
Adler et al	2018–2021	7	Clinical features and management of human monkeypox: a retrospective observational study in the UK	Headache 1	[29]
Learned et al	2003	3	Extended interhuman transmission of monkeypox in a hospital community in the Republic of the Congo, 2003	Headache 1, fatigue 2	[30]
Reynolds et al	2010	2	Short report: detection of human monkeypox in the Republic of Congo following intensive community education	Headache 1, fatigue 1	[31]
Formenty et al	2005	10	Human monkeypox outbreak caused by novel virus belonging to Congo Basin clade, Sudan, 2005	Myalgia 7, headache 5, fatigue 5	[32]
Ng et al	2019	1	A case of imported monkeypox in Singapore	Myalgia 1	[33]
Charniga et al	2022	21	Estimating the incubation period of monkeypox virus during the 2022 multi-national outbreak	Headache 21, fatigue 21	[34]
Pastula et al	2022	1	Two cases of monkeypox-associated encephalomyelitis – Colorado and the District of Columbia, July–August 2022	Encephalomyelitis 2	[12]
Cole J et al	2023	1	Monkeypox encephalitis with transverse myelitis in a female patient	Encephalitis 1, transverse myelitis 1	[13]