Table 2.

Trends in primary malignant bone tumor incidence and mortality rates (age-standardized to the Segi Standard Population) by area and sex: China, 2000 to 2015.

			Trend 1		Trend 2
Rate	Area	Sex	Years	APC (95% CI)	Years	APC (95% CI)
Incidence	All	Both	2000–2015	−2.2∗ (−3.0 to −1.4)	–	–
		Male	2000–2015	−2.5∗ (−3.4 to −1.6)	–	–
		Female	2000–2006	1.4 (−2.1 to 5.0)	2006–2015	−3.9∗ (−5.7 to −2.1)
	Urban	Both	2000–2015	−3.5∗ (−4.4 to −2.6)	–	–
		Male	2000–2015	−3.5∗ (−4.6 to −2.4)	–	–
		Female	2000–2015	−3.6∗ (−5.1 to −2.0)	–	–
	Rural	Both	2000–2003	17.5 (−1.9 to 40.8)	2003–2015	−3.2∗ (−5.3 to −1.1)
		Male	2000–2003	14.8 (−4.2 to 37.4)	2003–2015	−2.8∗ (−4.9 to −0.7)
		Female	2000–2007	6.8 (−0.3 to 14.4)	2007–2015	−7.0∗ (−12.1 to −1.7)
Mortality	All	Both	2000–2015	−4.8∗ (−5.7 to −3.9)	–	–
		Male	2000–2015	−5.1∗ (−6.2 to −4.1)	–	–
		Female	2000–2015	−4.3∗ (−5.2 to −3.4)	–	–
	Urban	Both	2000–2005	−8.9∗ (−11.8 to −5.9)	2005–2015	−3.1∗ (−4.1 to −2.0)
		Male	2000–2004	−10.6∗ (−15.3 to −5.7)	2004–2015	−4.1∗ (−5.2 to −3.0)
		Female	2000–2015	−3.6∗ (−5.1 to −2.1)	–	–
	Rural	Both	2000–2007	4.1 (−1.1 to 9.6)	2007–2015	−7.4∗ (−11.2 to −3.4)
		Male	2000–2007	4.0 (−2.5 to 10.8)	2007–2015	−7.1∗ (−11.9 to −2.2)
		Female	2000–2007	4.7 (−0.4 to 10.0)	2007–2015	−7.5∗ (−11.2 to −3.7)

^∗The APC is significantly different from zero (P < 0.05).

APC: Annual percentage change; CI: Confidence interval.