Table 5.

Logistic regression analyses of variables associated with the development of a hepatorenal syndrome (HRS-AKI) in patients with a history of ascites during the hospital stay (total cohort, n = 184)

Total cohort	OR (95% CI)	P value
Model 1a
CFS	1.809 (1.263–2.591)	0.001
MELD	1.120 (1.069–1.173)	<0.001
Hemoglobin	0.776 (0.645–0.933)	0.007
Model 2b
Frailty (CFS > 4)	3.717 (1.456–9.491)	0.006
MELD	1.117 (1.065–1.171)	<0.001
Hemoglobin	0.778 (0.646–0.938)	0.008
History of HRS-AKI	2.253 (1.018–4.990)	0.045

Logistic regression analyses were built based on a stepwise variable selection procedure.

CFS, Clinical Frailty Scale; 95% CI, 95% confidence interval; HRS-AKI, hepatorenal syndrome; MELD, model for end-stage liver disease; OR, odds ratio.

^aModel 1 included CFS as a metric variable. Not significant were albumin, sodium, white blood cell count, platelets, infection at study inclusion, sex, age, a history of hepatic encephalopathy, a history of hepatorenal syndrome, C-reactive protein, and alcoholic etiology of liver cirrhosis.

^bModel 2 included frailty (CFS > 4) as a dichotomous variable. Not significant were albumin, sodium, white blood cell count, platelets, infection at study inclusion, sex, age, a history of hepatic encephalopathy, C-reactive protein, and alcoholic etiology of liver cirrhosis.