Figure 4.

Increase in circulating IgA-switched B cells and T1 transitional cells in FAP. (a) Representative stains of different maturational stages of B cells within total circulating CD19⁺ cells in healthy control and FAP blood. Cells were gated as described in Materials and Methods. (b) Pooled data of B-cell subset staining as in (a). (c) Proportions of IgA- and IgG-switched B cells in blood, as a proportion of the total CD19⁺ population, determined as in (a). Median values ± 95% confidence intervals are shown; statistically significant differences between groups (Mann-Whitney tests) are indicated. FAP, familial adenomatous polyposis.