Table 1.
Clinical characteristics of the patients within the different groups
| Discovery (N = 97) | Validation (N = 93) | |||||
| Study group | Control group | P | Study group | Control group | P | |
| Total patients, n | 47 | 50 | 47 | 46 | ||
| Sex | ||||||
| Female, n (%) | 16 (34) | 23 (46) | 0.30 | 17 (36%) | 23 (50) | 0.21 |
| Age | ||||||
| Mean age at inclusion, yr (SD) | 52 (13.8) | 57 (3.1) | 0.02 | 56 (12.2) | 57 (3.5) | 0.64 |
| Mean age at diagnosis UC, y (SD) | 36 (18.4) | NA | NA | 38 (14.1) | NA | NA |
| UC-associated dysplasia, n | 20 | 25 | ||||
| Low-grade/high-grade, n (%) | 18/2 (90/10) | 25/0 (100/0) | ||||
| Sporadic adenoma, n | 21 | 0.61 | 19 | 0.99 | ||
| Low-grade/high-grade, n (%) | 20/1 (95/5) | 19/0 (100/0) | ||||
| Sex | ||||||
| Female, n (%) | 7 (35) | 9 (43) | 0.75 | 10 (40) | 10 (53) | 0.54 |
| Age | ||||||
| Mean age at inclusion, yr (SD) | 53 (13.0) | 58 (0.8) | 0.08 | 56 (12.9) | 58 (1.2) | 0.51 |
| Mean age at diagnosis UC, yr (SD) | 36 (14.6) | NA | NA | 38 (14.7) | NA | NA |
| Carcinomas, n | 12 | 19 | 12 | 20 | ||
| Sex | ||||||
| Female, n (%) | 3 (25) | 9 (47) | 0.27 | 5 (42) | 9 (45) | 0.99 |
| Age | ||||||
| Mean age at inclusion, yr (SD) | 56.9 (16.4) | 54.4 (2.9) | 0.52 | 60 (12.8) | 55 (2.7) | 0.09 |
| Mean age at diagnosis CRC, yr (SD) | 57.8 (17.5) | 54.4 (2.9) | 0.42 | 58 (12.5) | 55 (2.7) | 0.32 |
| Δt between diagnosis UC and CRC, yr (SD) | 13.5 (11.3) | NA | NA | 14.9 (9.3) | NA | NA |
| TNM, n (%) | ||||||
| In situ | 0 (0) | 6 (31.6) | 0 (0) | 0 (0) | ||
| I | 2 (16.7) | 9 (47.4) | 4 (33.3) | 9 (45) | ||
| II | 4 (33.3) | 0 (0) | 5 (41.7) | 2 (10) | ||
| 0.22 | 0.21 | |||||
| III | 1 (8.3) | 2 (10.5) | 3 (25) | 6 (30) | ||
| IV | 4 (33.3) | 2 (10.5) | 0 (0) | 1 (5) | ||
| Unknown | 1 (8.3) | 0 (0) | 0 (0) | 2 (10) | ||
| Locationa | ||||||
| Proximal/distal, n (%) | 3/8 (25/67) | 2/17 (11/89) | 0.33 | 3/6 (25/50) | 5/15 (25/75) | 0.67 |
| Unknown | 1 (8) | 0 (0) | 3 (25) | 0 (0) | ||
| Adjuvant treatment, n (%) | ||||||
| Yes/no | 5/5 (42/42) | 4/15 (21/79) | 0.20 | 9/3 (75/25) | 11/9 (55/45) | 0.45 |
| Unknown | 2 (16.7) | 0 (0) | 0 (0) | 0 (0) | ||
CRC, colorectal cancer; TNM, tumor, node, metastasis; UC, ulcerative colitis; NA, not applicable. P-values <0.05 are highlighted in bold.
a
Proximal and distal to the splenic flexure.