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. 2023 Aug 21;14:1244144. doi: 10.3389/fimmu.2023.1244144

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Copyright © 2023 Zhang, Zhang, Cui, Gong, Wang and Lin

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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Cellular interactions analysis. (A) Showing the number and intensity of interactions between different cell populations in the TME. (B, C) Bubble plots showing the possible ligand-receptor pairs between Tregs and other cell subpopulations in the TME. (D) Expression of key ligand-receptor pair genes in cell populations. (E) Heatmaps demonstrating the strength of outgoing and incoming signaling pathways in different cell subpopulations. (F) The roles played by different cell populations in the tumor microenvironment in the MIF signaling pathway network. (G) A scatter plot showing the distribution of different cell populations in the intensity of outgoing and incoming signaling interactions.