Table 2.
Comparison of the funobactam pharmacokinetic exposures achieved with each regimen administered in the funobactam dose-ranging studies in the murine neutropenic thigh infection model
| Funobactam dose | %fT > MIC for MIC (mg/L): | fAUC0-24 (mg.h/L) | fC max (mg/L) | ||||||||
|---|---|---|---|---|---|---|---|---|---|---|---|
| 0.25 | 0.5 | 1 | 2 | 4 | 8 | 16 | 32 | ||||
| Murine dose q6h SC | Clinical-equivalent dose q6h (1 h infusion) | ||||||||||
| 0.9 mg/kg | 31.25 mg | 86% | 57% | 29% | 0% | 0% | 0% | 0% | 0% | 17.84a | 1.74a |
| 1.8 mg/kg | 62.5 mg | 100% | 86% | 57% | 29% | 0% | 0% | 0% | 0% | 35.68b | 3.48b |
| 3.6 mg/kg | 125 mg | 100% | 100% | 86% | 57% | 29% | 0% | 0% | 0% | 71.36b | 6.95b |
| 7.2 mg/kg | 250 mg | 100% | 100% | 100% | 86% | 57% | 29% | 0% | 0% | 142.71a | 13.90a |
| 14.4 mg/kg | 500 mg | 100% | 100% | 100% | 100% | 94% | 67% | 39% | 10% | 363.70a | 36.15a |
Values calculated from observed PK data.
Linear interpolation between 7.2 and 0.9 mg/kg.