Table 2.
Distribution of acquired resistance genes cfr, optrA, poxtA and of 23S rDNA G2576T mutations in phenotypically linezolid-resistant and linezolid-susceptible E. faecium and E. faecalis isolates of the German CHROMAgar™ LIN-R multicentre study, 2021–2022
| E. faecium (N = 108) | cfr | optrA | poxtA | 23S rDNA G2576T | n | Percentage (%) |
|---|---|---|---|---|---|---|
| Susceptiblea (n = 27) | ||||||
| − | − | − | + | 6 | 22.0 | |
| − | − | − | − | 6 | 22.0 | |
| − | − | + | − | 14 | 52.0 | |
| − | + | − | − | 1 | 4.0 | |
| Total | 27 | 100 | ||||
| resistanta (n = 81) | ||||||
| − | − | − | + | 53 | 65.4 | |
| − | − | − | − | 1 | 1.2 | |
| − | − | + | − | 11 | 13.6 | |
| − | + | − | − | 14 | 17.3 | |
| − | + | + | − | 2 | 2.5 | |
| Total | 81 | 100 | ||||
| E. faecalis (N = 53) | cfr | optrA | poxtA | 23S rDNA G2576T | n | Percentage (%) |
| Susceptiblea (n = 13) | ||||||
| − | − | − | − | 3 | 23.1 | |
| − | − | + | − | 2 | 15.4 | |
| − | + | − | − | 7 | 53.8 | |
| + | + | + | − | 1 | 7.7 | |
| Total | 13 | 100 | ||||
| resistanta (n = 40) | ||||||
| − | − | − | + | 1 | 2.0 | |
| − | + | − | − | 38 | 95.0 | |
| − | + | + | − | 1 | 2.0 | |
| Total | 40 | 100 |
According to BMD results determined at the NRC.