Table 6.
NAPPA combined IV model: final parameter estimates and bootstrap results
| Drug: | Amoxicillin | Benzylpenicillin | Flucloxacillin | Piperacillin | ||||||||
|---|---|---|---|---|---|---|---|---|---|---|---|---|
| Parameter | Point estimate (RSE) | S (%) | BS (95% CI) | Point estimate (RSE) | S (%) | BS (95% CI) | Point estimate (RSE) | S (%) | BS (95% CI) | Point estimate (RSE) | S (%) | BS (95% CI) |
| TVCL | 16.4 (7.1) | — | 16.5 (14.0–18.8) | 7.17 (13) | — | 7.25 (5.29–9.61) | 14.6 (8.4) | — | 14.7 (12.5–17.5) | 8.59 (7.9) | — | 8.57 (7.44–10.1) |
| TVV | 46.2 (4.8) | — | 46.2 (42.4–51.0) | 11.8 (10.5) | — | 11.8 (9.86–14.6) | 23.3 (8.5) | — | 23.7 (20.3–28.3) | 18.6 (8.7) | — | 18.6 (15.4–22.1) |
| Var IIV (1) | 0.167 (26.4) | 39.2 | 0.152 (0.085–0.278) | 0.249 (25.6) | 60.6 | 0.238 (0.119–0.373) | 0.237 (19.6) | 58.8 | 0.225 (0.136–0.321) | 0.225 (32.2) | 59 | 0.220 (0.084–0.374) |
| Var IIV (2) | 0.045 (57.3) | 70.3 | 0.043 (0.005–0.099) | — | — | — | 0.024 (137.4) | 85.6 | 0.033 (0.0005–0.178) | — | — | — |
| Var prop RE | 0.135 (16.4) | 16.6 | 0.134 (0.092–0.184) | 0.241 (15.5) | 12.3 | 0.234 (0.168–0.315) | 0.179 (15.7) | 13.5 | 0.170 (0.123–0.229) | 0.212 (15.4) | 8.8 | 0.209 (0.153–0.280) |
| Var add RE | — | — | — | 0.012 (163.1) | 12.3 | 0.011 (0.001–0.836) | — | — | — | — | — | — |
| Parameter | Point estimate (RSE, %) | BS (95% CI) | ||||||||||
| T50 | 42.6 (9.1) | 43.5 (35.6–50.7) | ||||||||||
| Hill | 2.68 (6.3) | 2.80 (2.16–3.34) | ||||||||||
| M | 0.516 (13.1) | 0.486 (0.340–0.659) | ||||||||||
| N | 0.020 (50.5) | 0.022 (0.011–0.176) | ||||||||||
| Creat on CL | −0.302 (27.7) | −0.301 (−0.471 to −0.136) | ||||||||||
S shrinkage (%); BS, bootstrap; TVCL, typical value of clearance in L/h/70 kg; TVV, typical value of volume in L/70 kg; T50, maturation half time (PMA in weeks); Hill, Hill coefficient; M, fraction of CL on day of birth; N, rate of maturation post birth; Creat on CL, creatinine covariate on clearance; Var, variance; IIV (1), variance of IIV on CL; IIV (2), variance of IIV on V; prop RE, proportional component of the residual error; add RE, additive component of the residual error. All bootstrap results are presented as median (2.5th–97.5th percentiles).