Table 7.
Parameter estimates for separate oral flucloxacillin and amoxicillin PK models
| Parameter | Parameter estimates | |
|---|---|---|
| Flucloxacillin model | Amoxicillin model | |
| TVCL | 14.6 (fixed) | 16.4 (fixed) |
| TVV | 23.3 (fixed) | 46.2 (fixed) |
| T50 | 42.6 (fixed) | 42.6 (fixed) |
| Hill | 2.68 (fixed) | 2.68 (fixed) |
| M | 0.516 (fixed) | 0.516 (fixed) |
| N | 0.0202 (fixed) | 0.0202 (fixed) |
| Creat on CL | −0.302 (fixed) | −0.302 (fixed) |
| TVKA | 1.16 (RSE 28.4%) | 1.3 (RSE 52.4%) |
| F1 | 0.627 (RSE 8.1%) | 0.587(RSE 15.3%) |
| Var IIV (1) | 0.237 (fixed) (s: 8.1%) | 0.167 (fixed) (s: 11.8%) |
| Var IIV (2) | 0.024 (fixed) (s: 67.7%) | 0.045 (fixed) (s: 57.3%) |
| Var prop RE | 0.196 (RSE 14.5%) (s: 12.7%) | 0.141(RSE 14.2%)(s: 16.3%) |
TVCL, typical value of clearance in L/h/70 kg; TVV, typical value of volume in L/70 kg; TVQ, typical value of intercompartmental clearance in L/h/70 kg; TVV2, typical value of peripheral volume in L/70 kg; T50, maturation half time (PMA in weeks); Hill, Hill coefficient; M, fraction of CL on day of birth; N, rate of maturation post birth; Creat on CL, creatinine covariate on clearance; TVKA, typical value for the first-order absorption rate constant in h−1; F1, bioavailability term; Var, variance; Var IIV (1), variance of IIV on CL; Var IIV (2), variance of IIV on V; s, shrinkage; prop RE, proportional residual error.