Table 2.
Relative difference of metabolites between EarT2DM and LatT2DM groups.
| Metabolites | ESI+/− | EarT2DM vs HeaCG1 | LatT2DM vs HeaCG2 | ||||
|---|---|---|---|---|---|---|---|
| VIP | FC | P-value | VIP | FC | P-value | ||
| d-Mannose | + | 3.07 | 2.08 | < 0.001 | 2.98 | 2.00 | < 0.001 |
| l-Glutamate | − | 1.78 | 0.50 | < 0.001 | 1.94 | 0.40 | < 0.001 |
| Choline | + | 3.92 | 0.62 | < 0.001 | 4.28 | 0.60 | < 0.001 |
| 1-Stearoyl-sn-glycerol | + | 1.76 | 1.63 | < 0.001 | 2.15 | 1.68 | < 0.001 |
| 1-Stearoyl-2-hydroxy-sn-glycero-3-phosphocholine | + | 6.88 | 0.62 | < 0.001 | 6.97 | 0.59 | < 0.001 |
| Hypoxanthine | + | 2.74 | 0.37 | < 0.001 | 3.24 | 0.32 | < 0.001 |
| 2-Ethoxyethanol | + | 1.10 | 0.46 | < 0.001 | 1.59 | 0.38 | < 0.001 |
| Taurine | + | 1.02 | 0.69 | < 0.001 | 1.44 | 0.57 | < 0.001 |
| Dioctyl phthalate | + | 1.05 | 1.64 | < 0.001 | 1.33 | 1.94 | < 0.001 |
| Erucamide | + | 2.01 | 2.43 | < 0.001 | 1.48 | 1.63 | 0.019 |
| l-Pipecolic acid | + | 1.04 | 1.81 | < 0.001 | 1.04 | 1.82 | < 0.001 |
| 1-Palmitoyl-sn-glycero-3-phosphocholine | + | 8.53 | 0.71 | < 0.001 | 10.35 | 0.64 | < 0.001 |
| Acetylcarnitine | + | 2.14 | 0.73 | 0.002 | 1.99 | 0.72 | < 0.001 |
| 1-Oleoyl-sn-glycero-3-phosphocholine | + | 2.78 | 0.78 | 0.005 | 2.50 | 0.75 | < 0.001 |
| 1-Stearoyl-sn-glycerol 3-phosphocholine | + | 1.46 | 0.78 | 0.006 | 1.82 | 0.69 | < 0.001 |
| 1-Palmitoylglycerol | + | 1.05 | 1.35 | 0.020 | 1.57 | 1.15 | 0.004 |
| Alpha-D-Glucose | − | 10.92 | 2.32 | < 0.001 | 9.83 | 2.22 | < 0.001 |
| l-Pyroglutamic acid | − | 3.54 | 0.41 | < 0.001 | 3.12 | 0.39 | < 0.001 |
| d-Lyxose | − | 1.28 | 2.58 | < 0.001 | 1.10 | 2.15 | < 0.001 |
| d-Quinovose | − | 4.53 | 0.17 | < 0.001 | 3.46 | 0.25 | < 0.001 |
| Dulcitol | − | 2.99 | 0.22 | < 0.001 | 2.26 | 0.29 | < 0.001 |
| m-Chlorohippuric acid | − | 2.19 | 1.50 | < 0.001 | 1.93 | 1.41 | < 0.001 |
| 9-OxoODE | − | 1.99 | 0.32 | < 0.001 | 1.73 | 0.31 | < 0.001 |
| (+ −)12-HETE | − | 4.34 | 0.28 | < 0.001 | 3.76 | 0.26 | < 0.001 |
| l-Gulonic gamma-lactone | − | 3.98 | 2.42 | < 0.001 | 3.81 | 2.80 | < 0.001 |
| 1-Oleoyl-L-.alpha.-lysophosphatidic acid | − | 1.65 | 0.48 | < 0.001 | 1.55 | 0.42 | < 0.001 |
| 9(S)-HODE | − | 1.13 | 0.44 | < 0.001 | 1.22 | 0.30 | < 0.001 |
| 13(S)-HODE | − | 2.30 | 0.47 | < 0.001 | 2.16 | 0.40 | < 0.001 |
| L-Phenylalanine | − | 2.90 | 0.64 | < 0.001 | 2.54 | 0.62 | < 0.001 |
| 2-hydroxy-butanoic acid | − | 2.51 | 1.79 | < 0.001 | 2.11 | 1.83 | < 0.001 |
| 16-Hydroxypalmitic acid | − | 2.40 | 0.55 | < 0.001 | 2.43 | 0.51 | < 0.001 |
| Uridine | − | 1.09 | 0.81 | < 0.001 | 1.07 | 0.73 | < 0.001 |
| Norethindrone Acetate | − | 7.15 | 0.51 | < 0.001 | 6.93 | 0.48 | < 0.001 |
| Myristic acid | − | 4.48 | 0.62 | 0.001 | 4.85 | 0.54 | < 0.001 |
| Cis-9-Palmitoleic acid | − | 4.10 | 0.76 | 0.001 | 2.98 | 0.77 | 0.008 |
| Dodecanoic acid | − | 2.26 | 0.61 | 0.002 | 1.75 | 0.59 | < 0.001 |
| DL-lactate | − | 4.27 | 0.82 | 0.003 | 4.92 | 0.70 | < 0.001 |
| Palmitic acid | − | 10.78 | 0.80 | 0.003 | 12.91 | 0.75 | < 0.001 |
| Myristoleic acid | − | 1.90 | 0.63 | 0.004 | 2.37 | 0.52 | < 0.001 |
| All cis-(6,9,12)-Linolenic acid | − | 2.36 | 0.84 | 0.010 | 3.94 | 0.64 | < 0.001 |
| Nname,cis-9,10-Epoxystearic acid | − | 1.42 | 0.77 | 0.029 | 1.76 | 0.58 | < 0.001 |
| Ketoisocaproic acid | − | 8.59 | 1.32 | 0.048 | 1.24 | 1.41 | 0.019 |
| 1,2,3-Benzenetriol | + | 1.02 | 0.39 | < 0.001 | – | – | – |
| l-Leucine | + | 2.02 | 1.27 | < 0.001 | – | – | – |
| Betaine | + | 1.02 | 1.12 | 0.004 | – | – | – |
| l-Carnitine | + | 1.49 | 0.82 | 0.006 | – | – | – |
| Thioetheramide-PC | + | 4.49 | 1.49 | 0.023 | – | – | – |
| l-Glutamine | + | 1.03 | 1.09 | 0.040 | – | – | – |
| Dihydroxyacetone | − | 1.03 | 2.11 | < 0.001 | – | – | – |
| Pristanic acid | − | 1.19 | 0.65 | < 0.001 | – | – | – |
| Alpha-Tocopherol (Vitamin E) | − | 1.73 | 1.75 | < 0.001 | – | – | – |
| Cholesterol 3-sulfate | − | 5.25 | 1.74 | < 0.001 | – | – | – |
| 2'-Deoxy-d-ribose | − | 4.28 | 1.55 | 0.002 | – | – | – |
| Embelin | − | 1.23 | 0.70 | 0.013 | – | – | – |
| l-Isoleucine | − | 2.02 | 1.24 | 0.016 | – | – | – |
| Methylmalonic acid | − | 1.34 | 1.58 | 0.025 | 1.16 | 1.55 | 0.054 |
| Deoxycholic acid | − | 1.79 | 1.61 | 0.032 | – | – | – |
| d-Ribose | − | 1.30 | 1.40 | 0.058 | – | – | – |
| 3-Indolepropionic acid | − | 4.96 | 0.06 | 0.096 | – | – | – |
| SOPC | + | 1.12 | 1.14 | 0.074 | – | – | – |
| d-Proline | + | 1.33 | 1.14 | 0.087 | 1.60 | 1.21 | 0.008 |
| 3-Phenylpropanoic acid | − | 1.65 | 0.20 | 0.099 | 1.17 | 0.45 | < 0.001 |
| Alpha-Linolenic acid | − | – | – | – | 7.78 | 0.53 | < 0.001 |
| Linoleic acid | − | – | – | – | 19.72 | 0.67 | < 0.001 |
| Capric acid | − | – | – | – | 1.24 | 0.67 | < 0.001 |
| Pentadecanoic acid | − | – | – | – | 1.23 | 0.71 | < 0.001 |
| l-Arginine | − | – | – | – | 1.01 | 2.12 | 0.006 |
| 2E-Eicosenoic acid | − | – | – | – | 1.29 | 0.79 | 0.017 |
| 11(Z),14(Z)-Eicosadienoic acid | − | – | – | – | 1.40 | 0.83 | 0.025 |
| Heptadecanoic acid | − | – | – | – | 1.21 | 0.82 | 0.026 |
EarT2DM Early-onset T2DM, LatT2DM Late-onset T2DM, VIP variable importance in the projection, FC Fold change, ESI Electrospray ionization, SOPC 1-Stearoyl-2-oleoyl-sn-glycerol 3-phosphocholine.