Table 2.
PD motor subtypes: demographic and clinical characteristics.
| Indeterminate (n = 74) | PIGD (n = 297) | TD (n = 343) | p Value | |
|---|---|---|---|---|
| Age, years (median [IQR]) | 62.71 [56.22, 68.75]* | 67.00 [62.00, 71.00] | 63.18 [56.80, 69.02]* | < 0.001 |
| Gender female, n (%) | 29 (39.18) | 125 (42.09) | 122 (35.56) | 0.239 |
| Education, years (median [IQR]) | 14.00 [10.25, 16.00] * | 11.00 [9.00, 14.00] | 16.00 [13.00, 18.00] * | < 0.001 |
| Duration, years (median [IQR]) | 0.57 [0.26, 2.04] * | 3.14 [0.75, 6.60] | 0.40 [0.22, 1.01] * | < 0.001 |
| Age of onset, years (median [IQR]) | 59.84 [53.03, 67.40] | 62.00 [56.14, 67.00] | 61.08 [54.85, 66.82] | 0.252 |
| Hoehn and Yahr stage, n (%) | < 0.001 | |||
| Stage 1 | 21 (28.38)a | 59 (19.87) | 158 (46.06)* | |
| Stage 1.5 | 15 (20.27)a | 66 (22.22) | 12 (3.50)* | |
| Stage 2 | 36 (48.65) | 107 (36.03) | 172 (50.15)* | |
| Stage ≥ 2.5 | 2 (2.70)* | 36 (21.89) | 1 (0.30)* | |
| MDS-UPDRS I score (mean (SD)) | 4.73 (3.65)* | 3.66 (3.44) | 4.67 (3.82)* | 0.001 |
| MDS-UPDRS II score (mean (SD)) | 7.97 (4.16)*a | 9.89 (5.27) | 5.36 (3.85)* | < 0.001 |
| MDS-UPDRS III score (mean (SD)) | 15.89 (8.32) | 15.85 (7.15) | 19.32 (9.74)* | < 0.001 |
| MDS-UPDRS IV score (mean (SD)) | 0.30 (0.57)* | 1.26 (1.74) | 0.07 (0.30)* | < 0.001 |
| LED, mg/day (mean (SD)) | 108.45 (179.77) *a | 329.74 (282.84) | 39.94 (117.67) * | < 0.001 |
| MOCA score (median [IQR]) | 26.00 [25.00, 28.00] | 25.00 [24.00, 25.00] | 27.00 [25.00, 29.00]* | < 0.001 |
| Depression, n (%) | 36 (48.65)* | 236 (79.46) | 78 (22.74)* | < 0.001 |
| EDS, n (%) | 11 (14.86) | 27 (9.09) | 42 (12.24) | 0.259 |
| pRBD, n(%) | 20 (27.03) | 61 (20.54) | 111 (32.36)* | 0.003 |
Abbreviations: PD Parkinson’s disease, PIGD postural instability and gait disturbance, TD tremor dominant, MDS-UPDRS Movement Disorder Society revision of the Unified Parkinson’s Disease Rating Scale, MOCA Montreal Cognitive Assessment, EDS excessive daytime sleepiness, pRBD probable rapid eye movement sleep behavior disorder, SCOPA-AUT Scales for Outcomes in Parkinson’s Disease–Autonomic Dysfunction, IQR interquartile range, SD standard deviation.
*p < 0.05 compared with the PIGD subtype.
ap < 0.05 compared with the tremor-dominant subtype.