Table 1.
differentional expressed miRNA having roles in immune system response in endometriosis.
| miRNA | Species | Sample | Assessed cell line | Target regulator | Signal pathway | Mechanism | Study |
|---|---|---|---|---|---|---|---|
| miR-199a↓ | Human | Ectopic and eutopic endometrium from ovarian endometriomas patient(n=12) and control(n=12) | _ | IKKβ | NF-κB | miR-199a is downregulated in EMS patient; therefore, with the upregulation of IKKβ, the NF-κB pathway is more active. | (63) |
| miR-16↓ | Human | Ectopic and eutopic endometrium from patient(n=20) control(n=20) | _ | IKKβ | NF-κB | Downregulation of miR-16 can contribute to the activation of the NF-κB pathway. | (64) |
| miR-138↓ | Mouse | Peritoneal fluid from mice model of EMS | THP-1, ESCs cell line | P65 | NF-κB | Downregulation of miR-138 in THP-1 cocultured with uterine endothelial cells increases the NF-κB pathway in THP-1. | (65) |
| miR-182↓ | Human | Ectopic and eutopic endometrium from EMS patients(n=20) and Normal endometrium(n=20) |
_ | RELA | NF-κB | miR-182 inhibits the NF-κB signaling pathway by directly targeting RELA | (66) |
| miR-20a↑ | Human | Endometriotic lesions from pelvic endometriosis and ovarian endometrioma in patient with EMS (n=31) and normal endometrium from free EMS patients (n= 17), and 12 sets of paired eutopic and ectopic endometrial tissues from patients with EMS |
_ | DUSP-2 | HIF-1α | miR-20a, inhibiting DUSP-2, can provide prolonged activation of phosphorylated ERK, which raises PGE2 expression level and inflammation. | (70) |
| Let-7b↓ | Mouse | Endometriotic lesions were removed from peritoneum, patient sample(n=5), control sample(n=5) | _ | ER‐α, ER‐β, Cyp19a, KRAS 4A, KRAS 4B and IL‐6 | IL6, TLR4 | Treatment of mice with let-7b decreases inflammation by downregulation of IL6 and TLR4. | (71, 72) |
| miR-26b-5p↓, miR-215-5p↓, and miR-6795-3p↑ | Human | Serum samples were collected from patients with ovarian EMS lesions in stage 1 and 2 based on rASRM(American Society of Reproductive Medicine (n=12), stage 3-4(n=30), control sample(n=24) | _ | PTEN, CXCL2 | MAPK and PI3k-AKT | Regulating inflammation via MAPK and PI3k-AKT signaling pathways. | (73) |
| miR-17↓ | Human | Serum samples from EMS patient(n=80) and control(n=60) | _ | _ | _ | Downregulation of miR-17 By affecting IL4 and IL6 receptors could induce inflammation | (76) |
| miR-302a↑ | Human | Human endometrium samples from EMS patient(n=21) and control(n=36) | _ | COUP-TFII | _ | The aberrant expression of miR-302a by reduction of COUP-TFII and elevation of COX-2 can increase inflammation | (77) |
| miR-301a-3p↑ | Human | ectopic endometrial tissues and normal human serum | THP-1 | PTEN | PTEN-PI3K | Induction of M2 macrophage via PTEN-PI3K axis. | (83) |
| miR-887-5p↑ | Human | Peritoneal fluid, eutopic and ectopic endometrium | THP-1 | MTS1 | MAPK | Induction of M2 macrophage via MTS1-MAPK axis. | (84) |
| miR-146b↑ | Human | Endometrial tissue from patient with EMS(n=73), normal control(n=23), macrophages were extracted from peritoneal fluid | THP-1 | IRF5 | _ | Overexpression of miR-146b can lead to the reduction of IRF5 and subsequently decrease polarization of M1 macrophage. | (86) |
| miR-22-3p↑ | Human | pMQs were extracted from PF, and ESCs were isolated from ectopic endometrium in EMS patient(n=20) | _ | SIRT1 | NF-κB | miR-22-3p via targeting SIRT1 Increase NF-κB pathway in eESCs. | (87) |
| miR-15a-5p↓, miR-367-3p↓, miR34c-5p↓, miR-141-3p↓, miR-142-3p↓, miR-598-3p↑, miR-193a-p3↑, miR-501-5p↑, and miR-518d-3p↑ | Mouse | Endometriotic lesions were taken from xenograft mice model of peritoneal endometriosis. | Immortalized endometriotic epithelial cell line 12Z and stromal cell line 22B | _ | _ | Based on IPA, noted microRNAs were engaged in the inflammatory response. | (89) |
| miR-34c-5p and miR142-3p↑ | Mouse | Endometriotic lesions were taken from xenograft mice model of peritoneal endometriosis. | Immortalized endometriotic epithelial cell line 12Z and stromal cell line 22B | _ | _ | Based on IPA, noted microRNAs were engaged in macrophage phagocytosis malfunctions. | (89) |
| MIR1185-1-3p | Human and mouse | In human samples, 75 endometriotic tissues and 165 control samples were obtained by laparoscopy. In addition, NK cells were purified from PFMC of both human and mouse. | _ | PTGS2 | _ | Downregulation of the mentioned miRNA can induce differentiation of the low cytotoxic NK cells by increasing of COX-2 and PGE-2 | (28) |
“↑” symbol means the expression of the written non-coding RNA is upregulated.
“↓” symbol means the expression of the written non-coding RNA is downregulated.
“-” there is no information about that subject.