Table 2.

differentional expressed LncRNAs having roles in immune system response in endometriosis.

LncRNA	Species	Sample	Assessed cell line	Target regulator	Mechanism	Study
H19↓	Human	PFMC from ovarian endometriotic cysts(n=20), control sample(n=16), PBMC from healthy fertile women, and endometrial tissues which are free in terms of EMS	_	miR-342-3p	Downregulation of H19 via negative regulation of the miR-342-3p/IER3 axis promotes TH17 differentiation and IL17 production. Additionally, H19 can regulate miR-17, an upstream regulator of TLR4.	(121)
MALAT-1↑	Human	Ectopic endometrial tissue (n=28), normal endometrial tissue(n=17)	_	miR-142-3p	Mediating inflammation by sponging miR-142-3p, an upstream regulator of CXCR7, and production of TNF-α, IL-1β, and IL-6.	(93)
LINC00339↑	Human	Endometrium and endometriotic lesion from EMS(n=251), control group(n=30)	T-HESC	DDX58, IFIH1, OAS2, OAS3, IFIT1, IFIT3, IFITM3, MX1, STAT1, STAT3, IFNE	Overexpression of LINC00339 causes Upregulation of PRRs and inflammation	(111)
HOTAIR↑	Human	Endometrial tissues sample from ovarian endometrial cysts(n=50), control sample(n=50)	_	miR-761	HOTAIR, via regulation of the miR-761/HDAC1 axis and activation of STAT3-mediated inflammation, takes part in the inflammatory response.	(114)
LINC01018↑	Human	GSE121406, GSE105764, GSE105765	_	hsa-miR-182-5p	Regulation of IFN-γ and TNF-α by sponging hsa-miR-182-5p	(115)
LINC01272↑	Human	GSE121406, GSE105764, GSE105765	_	hsa-miR-182-5p	Upregulation of LINC01272 regulates CHL1 by mediating hsa-miR-182-5p.	(115)
CHL1-AS1↑	Human	Ectopic endometrial tissue from ovarian EMS cysts(n=50), control sample(n=50), Peritoneal fluid	_	miR-610	CHL1-AS1 transported by exosomes enters eESCs, and by Sponging miR-610 led to the accumulation of MDM2 resulting proliferation, migration, and invasion of eESCs	(120)
AFAP1-AS1↑	Human	Paired ectopic and eutopic endometria(n=36)	_	TNFSF13	Have a role in B cells development and maturation.	(124)
MIR202HG↑	Human	Paired ectopic and eutopic endometria(n=36)	_	PCSK2/PC2	Modulating HLA-I binding peptide	(124)
LINC02381↑	Human	Normal endometria(n=6), eutopic endometria(n=6), and ectopic endometria(n=6)	_	hsa-miR-1301-3p	By sponging hsa-miR-1301-3p affects on CD84	(129)
LINC01140↑, MSC-AS1↑, HAGLR↑, CKMT2-AS1↑, JAKMIP2-AS1↑, and AL365361.1↑	Human	Ectopic endometria sample(n=8), eutopic endometria sample(n=8)	_	_	Positive regulation of phagocytosis in myeloid leukocyte and lymphocyte activation	(132)