Table 2.
Nanofibers in clinical trials.
| Sr. No. | Study Title | Condition/disease | Interventions/treatment | Sponsors | Reference |
|---|---|---|---|---|---|
| 1. | Rotator cuff healing using a nanofiber scaffold in patients greater than 55 years | Rotator cuff tears | Device: Nanofiber scaffold | Atreon Orthopedics | [112] |
| 2. | Antimicrobial effect of modified antibiotic nanofibers for regenerative endodontics procedures | Necrosis, Pulp | Procedure: electrospun TAP nanofibers | Cario University | [113] |
| 3. | Evaluation of marginal integrity of hydroxyapatite nanofiber reinforced flowable composite versus conventional resin-based flowable composite in initially demineralized pits and fissure: a one-year, randomized clinical trails | Marginal integrity of hydroxyapatite nanofiber reinforced flowable composite | Other: Conventional resin-based flowable composite Other: Hydroxyapatite nanofiber reinforced flowable composite |
Cario University | [114] |
| 4. | The retention rate of hydroxyapatite nanofiber reinforced flowable composite versus conventional | The retention rate of flowable composite in demineralized pits and fissures | Other: Hydroxyapatite nanofiber reinforced flowable composite Other: conventional resin-based flowable composite |
Cario University | [115] |
| 5. | To investigate the feasibility and efficacy of a novel biomimetic poly-l-lactide (PLLA) nanofiber membrane in repairing anterior urethral strictures. | Urethral stricture | Underwent urethral reconstruction using a biomimetic PLLA membrane | Shanghai Sixth People's Hospital | [116] |
| 6. | Clinical study of functional electrospun nanofibers capturing circulating tumor cells from patients with ovarian cancer to predict the efficacy and prognosis of patients with ovarian cancer | Ovarian Cancer | CTC device The CTCs of ovarian cancer patients at different stages were captured by electrospinning nanofibers | Xinhua Hospital, Affiliated with the Medical College of Shanghai Jiaotong University | [117] |
| 7. | Clinical study of new liposome nanofibers patches for transdermal drug delivery containing ebracteolata Hayata in treating actinic keratosis. | Actinic keratosis | Drugs for external use | Shuguang Hospital, affiliated with the Shanghai University of Traditional Chinese Medicine | [118] |
| 8. | A novel drug delivery system using acyclovir nanofiber patch for topical treatment of recurrent herpes labialis: a randomized clinical trial | Herpes Labialis | Acyclovir nanofiber patch | Esfahan University of Medical Sciences | [119] |